One thing that may be a reality is having players inactive for 1-2+ weeks due to Covid19 positive tests. 2 weeks may be the max as if someone goes longer they probably experiencing a more serious case and may just go on IR.

This is the last update I saw about the rosters and practice squads almost a month ago

As of right now, team roster sizes will stay at 53 players, but practice squads will see a bump in capacity.

Per Mark Maske of The Washington Post, practice squads can now roster 16 players and can protect a maximum of four players per week from being poached by other teams.
I wonder if it will be enough?

12 guys on practice squad who can be taken by others teams and 4 guys protected.